[Lys1,Pro2,5,Arg3,4,Tyr6]VIP, human, porcine, rat, ovine H-Lys-Pro-Arg-Arg-Pro-Tyr-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn-NH2
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VIP antagonist, a hybrid of neurotensin (6-11) and VIP (7-28), is a competitive antagonist of VIP-binding to glial cells. In rats with reduced masculine potency, it significantly inhibits VIP-stimulated sexual behavior. It antagonizes VIP receptors on non-small cell lung cancer cells, thereby inhibiting tumor growth in vivo and in vitro.
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