α-Conotoxin MII

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Alpha-Conotoxin MII H-Gly-Cys(1)-Cys(2)-Ser-Asn-Pro-Val-Cys(1)-His-Leu-Glu-His-Ser-Asn-Leu-Cys(2)-NH2

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α-Conotoxin MII is a nicotinic acetylcholine receptor antagonist. It is highly potent, selective and competitive for α3β2 subunit. Its IC50 value is 0.5-3.5 nM at α3β2 expressed in Xenopus oocytes. It also potently prevents β3-containing neuronal nicotinic receptors.

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