(S)-3-Hydroxy Midostaurin

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Purity: ≥95%

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(S)-CGP52421 Benzamide, N-((3S,9S,10R,11R,13R)-2,3,10,11,12,13-hexahydro-3-hydroxy-10-methoxy-9-methyl-1-oxo-9,13-epoxy-1H,9H-diindolo(1,2,3-gh:3',2',1'-lm)pyrrolo(3,4-j)(1,7)benzodiazonin-11-yl)-N-methyl-

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(S)-3-Hydroxy Midostaurin, a potent kinase inhibitor with IC50s of <400 nM for 13 kinases (VEGFR-2, TRK-A, FLT3, et), is a minor metabolite of midostaurin undergoing by the hepatic CYP3A4 enzyme. It has the potential for the treatment of acute myeloid leukemia (AML).

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