(Z)-4EGI-1

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(2Z)-2-{[4-(3,4-Dichlorophenyl)-1,3-thiazol-2-yl]hydrazono}-3-(2-nitrophenyl)propanoic acid Benzenepropanoic acid, α-[2-[4-(3,4-dichlorophenyl)-2-thiazolyl]hydrazinylidene]-2-nitro-, (αZ)-

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(Z)-4EGI-1, the Z-isomer of 4EGI-1, is an inhibitor of eIF4E/eIF4G interaction and translation initiation and has anticancer activity. It effectively binds to eIF4E with an IC50 of 43.5 μM and a Kd of 8.74 μM.

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