2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine

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Purity: ≥98%

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PhIP 1-methyl-6-phenyl-1H-imidazo[4,5-b]pyridin-2-amine

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Appearance:Crystalline Solid
Application:For research use only.
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2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is a food-derived carcinogen that is found in high temperature-cooked fish and meat. In humans, PhIP is metabolized by the cytochrome (CYP) P450 isoform CYP1A2 and conjugated by N-acetyltransferase or sulfotransferase to a metabolite that reacts with DNA to form adducts, which are directly correlated with increased risk of breast, colon, and prostate cancers.

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