A-395

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Purity: ≥95%

Keywords

3-Pyrrolidinamine, 1-(7-fluoro-2,3-dihydro-1H-inden-1-yl)-N,N-dimethyl-4-[4-[4-(methylsulfonyl)-1-piperazinyl]phenyl]-, (3R,4S)- (3R,4S)-1-(7-Fluoro-2,3-dihydro-1H-inden-1-yl)-N,N-dimethyl-4-{4-[4-(methylsulfonyl)-1-piperazinyl]phenyl}-3-pyrrolidinamine

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A-395 is an antagonist of polycomb repressive complex 2 (PRC2) protein-protein interactions, and can effectively inhibit the trimeric PRC2 complex (EZH2-EED-SUZ12) with an IC50 of 18 nM.

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