Amarogentin 21018-84-8
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Amarogentin exhibits anti-oxidative, anti-tumour, and anti-diabetic activities. Amarogentin promotes apoptosis, arrests G2/M cell cycle and downregulates of PI3K/Akt/mTOR signalling pathways and displays immunomodulatory effects in human mast cells and keratinocytes. It inhibits the growth of SNU-16 human gastric cancer cells (IC50 = 12.4 μM) and increases apoptosis when used at a concentration of 50 μM. Amarogentin dose-dependently reduces tumor growth in a SNU-16 nude mouse xenograft model. Amarogentin may offer therapeutic potential for preventing or treating thromboembolic disorders, it prevents platelet activation through the inhibition of PLC γ2-PKC cascade and MAPK pathway.
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