6,7-Dimethoxy-N-(2-methyl-4-phenoxyphenyl)quinazolin-4-amine APS-2-79
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APS-2-79 is a small molecule antagonist of MEK phosphorylation by RAF through direct binding of the KSR active site, and antagonizes oncogenic Ras signalling (IC50 value 120 nM against ATP-biotin probe-labelling of KSR2).
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