Araguspongin B

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Araguspongin B

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Araguspongin B is a compound isolated from Pacific basin sponges. It shows notable vasodilatory properties. Araguspongin B antagonizes the calcium-releasing action of inositol 1,4,5-trisphosphate at the receptor level with an IC50 value of 0.6 μM in cerebral microsomes. It is nearly as potent as xestospongin C as an antagonist of the IP3 receptor.

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