AZD3229

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AZD-3229 AZD 3229

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Application:For research use only.
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AZD3229 is a potent pan-KIT mutant inhibitor for the treatment of gastrointestinal stromal tumors. It selectively inhibits growth of c-Kit mutant with GI50s of 1971 nM and PDGFR mutant with GI50s of 122 nM). AZD3229 demonstrates excellent cross-species pharmacokinetics, shows strong pharmacodynamic inhibition of target, and is active in several in vivo models of GIST.

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