BAY1125976

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BAY-1125976 BAY 1125976

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BAY1125976 is a selective allosteric AKT1/2 inhibitor, which exhibits high efficacy on AKT signaling-dependent tumor growth in mouse models. In in vitro kinase activity assays, BAY 1125976 potently and selectively inhibited the activity of full-length AKT1 and AKT2 by binding into an allosteric binding pocket formed by kinase and PH domain.

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