Bromoenol lactone

Min.Order / FOB Price:Get Latest Price

0	Negotiable

Min.Order :0
Purity: ≥95%

Keywords

BEL Haloenol lactone

Quick Details

Appearance:Crystalline Solid
Application:For research use only.
PackAge:
ProductionCapacity:
Storage:
Transportation:

Superiority:

We provide customized and high-quality Bromoenol lactone product for your project.

Details:

BEL is a selective, potent, irreversible, mechanism-based inhibitor of myocardial cytosolic calcium-independent phospholipase A2 (iPLA2) with a Ki value of 180 nM. BEL induces the proteolysis of procaspase-9 and procaspase-3 and increases cleavage of poly (ADP-ribose) polymerase. BEL also inhibits macrophage iPLA2 in a concentration-dependent manner with an IC50 value of 60 nM and is an effective enzyme-activated irreversible inhibitor of chymotrypsin Ki of 636 nM. Long term treatment with BEL increased annexin-V binding to the cell surface and nuclear DNA damage.

View All