Imidodicarbonimidic diamide, N-butyl- Biguanide, 1-butyl-
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Buformin, clinically used for diabetes mellitus, is known to improve resistance to insulin in patients. It suppresses the expression of glyceraldehyde 3-phosphate dehydrogenase. Buformin is a potent AMPK activator and acts as an orally active biguanide antidiabetic agent.
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