BW 755C

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0	Negotiable

Min.Order :0
Purity: ≥95%

Keywords

BW755C BW-755C

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Appearance:Crystalline Solid
Application:Anti-Inflammatory Agents, Non-Steroidal
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Storage:Store at -20°C
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Constitutive cyclooxygenase (COX-1) is present in cells under physiological conditions, whereas COX-2 is induced by some cytokines, mitogens, and endotoxin in pathological conditions, such as inflammation. Since 5-lipoxygenase (5-LO) oxidizes arachidonic acid to 5-hydroperoxyeicosatetraenoic acid. BW 755C is a dual inhibitor of 5-lipoxygenase (5-LO) and cyclooxygenase (COX) pathways. It inhibits 5-LO with IC50s of 0.75 μM, COX-1 with IC50s of 0.65 μg/ml, and COX-2 with IC50s of 1.2 μg/ml. BW 755C may also inhibit other LO pathways in vivo.

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