2-methoxy-5-[(Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenol 1-(3,4,5-trimethoxyphenyl)-2-(3'-hydroxy-4'-methoxyphenyl)ethene
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D-64131, under the IUPAC name (5-methoxy-1H-indol-2-yl)-phenylmethanone, is a 2-aroylindole derivative that inhibits tubulin polymerization.
In vitro: Inhibits tumor cell proliferation (IC50 = 74 nM);
In vivo: After oral administration, prevents tumor models growing in mice
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