Dehydroaltenusin

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Purity: 95%

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6H-Dibenzo(b,d)pyran-2,6(4ah)-dione, 3,7-dihydroxy-9-methoxy-4a-methyl-, (4aS)- (S)-Dehydroaltenusin

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Application:Enzyme Inhibitors
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Dehydroaltenusin is a selective eukaryotic DNA polymerase α inhibitor and a type of antibiotic produced by a fungus (IC50 = 0.68 μM). Dehydroaltenusin inhibits mammalian pol α activity. Dehydroaltenusin arrests the cancer cell cycle at the S-phase and triggers apoptosis. Dehydroaltenusin possesses anti-tumor activity against human adenocarcinoma tumor in vivo.

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