D-NMAPPD

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Purity: ≥98%

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(1R,2R)-B13 CAY10466

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Appearance:Crystalline Solid
Application:For research use only.
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D-NMAPPD is an inhibitor of ceramidase. It induces cell death in SW403 colon adenocarcinoma cells in a time- and concentration-dependent manner but doesn't have effect on viability of rat hepatocytes, Kupffer cells, or sinusoidal endothelial cells when used at a concentration of 100 mM. It also increases intracellular ceramide accumulation and cytochrome C release and induces apoptosis in SW403 cells.

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