1-{4-[2-(5-methylfuran-2-yl)quinoline-4-carbonyl]piperazin-1-yl}ethan-1-one
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E1231 is an orally active activator of Sirtuin 1 (SIRT1) (EC50=0.83 μM). E1231 protects from experimental atherosclerosis and lowers plasma cholesterol and triglycerides by enhancing ABCA1 expression.
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