N-[(4-bromophenyl)methyl]-4-chloro-N-[(3R)-hexahydro-2-oxo-1H-azepin-3-yl]-Benzenesulfonamide N-(4-Bromobenzyl)-4-chloro-N-[(3R)-2-oxo-3-azepanyl]benzenesulfonamide
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ELN318463, a selective γ-secretase inhibitor of amyloid precursor protein (APP), has differential inhibition of presenilin (PS1)- and PS2-comprised γ-secretase with EC50s of 12 and 656 nM for PS1 and PS2, respectively. It is 51-fold more selective for PS1.
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