CasNo.1072145-33-5,ERRα antagonist-1,N-[3-(4,5-DIHYDRO-2-THIAZOLYL)-2-THIAZOLIDINYLIDENE]-5H DIBENZO[A,D] CYCLOHEPTEN-5-AMINE(1072145-33-5) Suppliers

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Purity: ≥95%

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N-(3-(4,5-Dihydrothiazol-2-yl)thiazolidin-2-ylidene)-5H-dibenzo[a,d][7]annulen-5-amine ERRa antagonist-1

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ERRα antagonist-1, a selective and high affinity antagonist of estrogen-related receptor α (ERRα), inhibits interaction of ERRα with Proliferator-activated Receptor γ Coactivator-1α (PGC-1α) and PGC-1β with IC50s of 170 and 180 nM, respectively. It does not inhibit the interaction of either ERRβ or ERRγ with PGC-1α and PGC-1β coactivator, and also does not inhibit interaction of ERα or ERβ with PGC-1α or SRC-1.