Gemcitabine elaidate hydrochloride

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Purity: ≥97%

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CO-101 hydrochloride CP-4126 hydrochloride

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Gemcitabine elaidate is a lipophilic prodrug form of the nucleoside analog gemcitabine that contains an elaidic acid moiety. Gemcitabine elaidate inhibits growth of gemcitabine-sensitive L1210/L5, BCLO, and A2780 cells (IC50s = 0.0033, 0.0042, and 0.0025 μM, respectively) but not cytarabine-resistant L4A6 and Bara-C cells (IC50s = 16 and 13 μM, respectively) or gemcitabine-resistant AG6000 cells (IC50 = 91 μM).

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