5,7-Dimethoxy-3',4'-diprenyloxyisoflavone 4H-1-Benzopyran-4-one, 3-[3,4-bis[(3-methyl-2-buten-1-yl)oxy]phenyl]-5,7-dimethoxy-
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Glabrescione B is the first compound to bind the Hedgehog (Hh) modulator Gli1 and impair its activity by interfering with Gli1-DNA interaction. It inhibits the growth of Hedgehog-dependent tumor cells, the self-renewal ability, and clonogenicity of tumor-derived stem cells.
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