IRE1α kinase-IN-2

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1-(4-(8-Amino-3-isopropylimidazo[1,5-a]pyrazin-1-yl)naphthalen-1-yl)-3-(3-(trifluoromethyl)phenyl)urea Urea, N-[4-[8-amino-3-(1-methylethyl)imidazo[1,5-a]pyrazin-1-yl]-1-naphthalenyl]-N'-[3-(trifluoromethyl)phenyl]-

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IRE1α kinase-IN-2, a potent IRE1α kinase inhibitor (EC50 = 0.82 μM), inhibits IRE1α kinase autophosphorylation (IC50 = 3.12 μM), and inhibits XBP1 mRNA splice in WT cell lines.

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