JNJ-64619178

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Purity: 95%

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(1S,2R,3S,5R)-3-[2-(2-Amino-3-bromoquinolin-7-yl)ethyl]-5-(4-aminopyrrolo[2,3-d]pyrimidin-7-yl)cyclopentane-1,2-diol

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Application:Enzyme Inhibitors
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JNJ-64619178 is a selective PRMT5 inhibitor with potent in vitro and in vivo activity. JNJ-64619178 binds simultaneously to the SAM- and protein substrate- binding pockets of the PRMT5/MEP50 complex with a pseudo-irreversible mode-of-action. It can be developed as the treatment of some malignancies.

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