CasNo.155271-17-3,KF21213,8-[(E)-2-(2,3-Dimethyl-4-methoxyphenyl)vinyl]-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione(155271-17-3) Suppliers

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Purity: 95%

Keywords

8-[2-(4-methoxy-2,3-dimethylphenyl)ethenyl]-1,3,7-trimethylpurine-2,6-dione 8-(2,3-dimethyl-4-methoxystyryl)-1,3,7-trimethylxanthine

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KF21213 is a highly selective ligand for mapping CNS adenosine A2A receptors. The Ki values of KF21213 were 3.0 nM for the adenosine A2A receptors and >10,000 nM for the adenosine A1 receptors. KF21213 showed a slightly higher affinity for the A2A receptors and a much lower affinity for the A1 receptors than KF18446 (Ki= 5.9 nM for A2A receptors and Ki= 1600 nM for the A1 receptors).