L-Buthionine sulfoximine

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Purity: ≥98% by HPLC

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L-Buthionine-(S,R)-Sulfoximine (2S)-2-Amino-4-(S-butylsulfonimidoyl)butanoic acid

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L-Buthionine sulfoximine is an irreversible glutathione-synthesis inhibitor developed as a chemotherapeutic agent. It inhibits glutathione biosynthesis and causes depletion of cellular glutathione levels. Study showed that L-Buthionine sulfoximine synergistically enhanced melphalan activity (inducing 2-4 logs of cell kill) against multiple myeloma cell lines.

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