L-γ-Glutamyl-S-[(1R,2E,4E,6Z,9Z)-1-[(1S)-4-carboxy-1-hydroxybutyl]-2,4,6,9-pentadecatetraen-1-yl]-L-cysteine L-γ-Glutamyl-S-[(4S,5R,6E,8E,10Z,13Z)-1-carboxy-4-hydroxy-6,8,10,13-nonadecatetraen-5-yl]-L-cysteine
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Leukotriene F4 is a cysteinyl-leukotriene formed by incubation of LTE4 with γ-glutamyltranspeptidase and glutathione. It induces bronchoconstriction with an ED50 of 16 μg/kg. It is a weak agonist in its ability to contract vascular smooth muscle. The rank order of potency of the cysteinyl-leukotrienes to contract vascular smooth muscle is LTD4 > LTC4 > LTE4 >> LTF4.
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