Quino[2',3':3,4]pyrrolo[2,1-b]quinazolin-11(13H)-one
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Luotonin A is an alkaloid isolated from a Chinese traditional herbal medicine Peganum nigellastrum. It binds to and stabilizes the topoisomerase I-DNA binary complex, leading to DNA breakage and cell death (IC50 = 5.07 - 12.6 μM).
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