LY2811376

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Purity: ≥95%

Keywords

4H-1,3-Thiazin-2-amine, 4-[2,4-difluoro-5-(5-pyrimidinyl)phenyl]-5,6-dihydro-4-methyl-, (4S)- (4S)-4-[2,4-Difluoro-5-(5-pyrimidinyl)phenyl]-5,6-dihydro-4-methyl-4H-1,3-thiazin-2-amine

Quick Details

Appearance:Crystalline Solid
Application:For research use only.
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Storage:Store in a cool and dry place and at 2-8°C for short term (days to weeks) or -20°C for long term (months to years)
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Details:

LY2811376, under the IUPAC name (4S)-4-(2,4-difluoro-5-pyrimidin-5-ylphenyl)-4-methyl-5,6-dihydro-1,3-thiazin-2-amine, is the first orally available non-peptidi Beta secretase (BACE) inhibitor (IC50 = 239-249 nM) with the potent effect of treating Alzheimer's Disease. In vivo, LY2811376 inhibits BACE1 activity by concomitantly reducing C99 and sAPPb, the two primary APP cleavage products generated by BACE1. In vitro, LY2811376 demonstrates concentration-dependent inhibition of hBACE1 with an IC50 of 239 and 249 nM.

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