MID-1

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4-Ethoxy-N-(5-nitrothiazol-2-yl)benzamide Benzamide, 4-ethoxy-N-(5-nitro-2-thiazolyl)-

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MID-1 is a disruptor of the interaction of MG53-IRS-1 (Mitsugumin 53-insulin receptor substrate-1). MID-1 disrupts the molecular association between MG53 with IRS-1 and eliminates MG53-induced IRS-1 ubiquitination and degradation in skeletal muscle, resulting in increased IRS-1 expression level, insulin signaling and glucose uptake.

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