Natalizumab

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Immunoglobulin G4, anti-(human integrin R4) (human-mouse monoclonal AN100226 c4-chain), disulfide with human-mouse monoclonal AN100226 light chain, dimer Tysabri

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Natalizumab, a recombinant and humanized IgG4 monoclonal antibody, binds to α4β1-integrin and blocks its interaction with vascular cell adhesion molecule-1 (VCAM-1). It is used to treat relapsing remitting multiple sclerosis and Crohn's disease. It is also the first targeted therapy to block an important mechanism for lymphocyte entry to the CNS and thus prevent acute demyelinating relapses.

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