Nebentan potassium

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YM598 Ethenesulfonamide, N-[6-methoxy-5-(2-methoxyphenoxy)[2,2'-bipyrimidin]-4-yl]-2-phenyl-, potassium salt (1:1), (1E)-

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Nebentan potassium, a potent, selective and orally active non-peptide endothelin ETA receptor antagonist produced by modification of Bosenan, inhibits the binding of [125I] endothelin-1 to cloned human endothelin ETA and ETB receptors with Kis of 0.697 and 569 nM, respectively. It can improve the progression of cor pulmonale and myocardial infarction in vivo.

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