L-leucyl-L-prolyl-L-arginyl-L-leucyl-L-leucyl-L-histidyl-L-threonyl-L-α-aspartyl-L-seryl-L-arginyl-L-methionyl-L-alanyl-L-threonyl-L-isoleucyl-L-α-aspartyl-L-phenylalanyl-L-prolyl-L-lysyl-L-lysy... Leu-Pro-Arg-Leu-Leu-His-Thr-Asp-Ser-Arg-Met-Ala-Thr-Ile-Asp-Phe-Pro-Lys-Lys-Asp-Pro-Thr-Thr-Ser-Leu-Gly-Arg-Pro-Phe-Phe-Leu-Phe-Arg-Pro-Arg-Asn-NH2
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Neuromedin S, a novel neuropeptide of 36 amino acids isolated from rat brain as an endogenous ligand for the orphan G protein-coupled receptors FM-3/GPR66 and FM-4/TGR-1, is a potent, endogenous neuromedin U receptor agonist (EC50 values are 65 and 91 pM at NMU1 and NMU2 respectively). Central NMS may exert a physiological antidiuretic action via vasopressin release.
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