Nocodazole

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Purity: 95%

Keywords

methyl N-[6-(thiophene-2-carbonyl)-1H-benzimidazol-2-yl]carbamate nocodazole

Quick Details

Appearance:Pale beige solid
Application:For research use only.
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Storage:Store in a cool and dry place and at 0 - 4°C for short term (days to weeks) or -63°C for long term (months to years).
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Details:

Nocodazole, also called Oncodazole, reversibly inhibits microtubule polymerization so it has anti-neoplastic effect. It is inhibitor of Abl (IC50= 0.21 μM), Abl(E255K) (IC50= 0.53 μM)and Abl(T315I) (IC50= 0.53 μM).
in vitro: a high-affinity ligand for Abl phosphorylated (Kd= 0.091 μM), c-Kit (Kd= 1.6 μM), BRAF (Kd= 1.8 μM), and MEK (Kd= 1.6 μM)
in vivo: combined with Ketoconazole strongly enhances apoptosis of COLO 205 tumor xenografts

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