Nolatrexed

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Purity: 95%

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2-amino-6-methyl-5-(pyridin-4-ylthio)quinazolin-4(3H)-one NSC648316

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Application:Antimetabolites, Antineoplastic
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Nolatrexed occupies the folate binding site of thymidylate synthase, resulting in inhibition of thymidylate synthase activity and thymine nucleotide synthesis with subsequent inhibition of DNA replication, DNA damage, S-phase cell cycle arrest, and caspase-dependent apoptosis. This agent also exhibits radiosensitizing activity.

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