(Z)-2-(1H-indol-3-yl)-3-pyridin-3-ylprop-2-enenitrile 2-(1H-indol-3-yl)-3-(pyridin-3-yl)acrylonitrile
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Paprotrain is a reversible, non-ATP competitive inhibitor of the kinesin MKLP-2 with selectivity over 12 other members of the kinesin superfamily, including the closely-related MKLP-1. Paprotrain shows a moderate inhibition activity on DYRK1A (IC50 = 5.5 μM).
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