PF 06551600 malonate

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Purity: ≥98% by HPLC

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1-[(2S,5R)-2-Methyl-5-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-1-piperidinyl]-2-propen-1-one malate

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PF 06551600 is a potent and selective JAK3 inhibitor with IC50 value of 33.1 μM, exhibiting >1,000-fold selectivity over JAK1 and JAK2. It inhibits phosphorylation of STAT5, induced by IL-2, IL-4, IL-7 and IL-15. It also inhibits Th1 and Th17 T-cell differentiation and function in vitro.

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