PF-06840003

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Purity: 95%

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EOS200271, EOS-200271 EOS 200271

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Application:antitumor drug
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PF-06840003 is a highly selective inhibitor of IDO1 (IC50 = 0.41mcM), an immunosuppressive enzyme induced by multiple cancers. Study in vitro showed that PF-06840003 led to IDO-1-induced T-cell anergy. Study in vivo revealed that it significantly suppressed tumor growth in combination with avelumab in mouse model.

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