(-)-Picrotoxinin (1aR,2aR,3S,6R,6aS,8aS,8bR,9R)-Hexahydro-2a-hydroxy-8b-methyl-9-(1-methylethenyl)-3,6-methano-8H-1,5,7-trioxacyclopenta[ij]cycloprop[a]azulene-4,8(3H)-dione
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Picrotoxinin, a chloride channel blocker used as a potent convulsant, is a noncompetitive GABAA receptor antagonist that negatively modulates the effect of GABA on GABAA receptors.
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