PL 017

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Purity: 95%

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Tyr-Pro-MePhe-D-Pro PL 017

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PL 017, a morphiceptin analog, is a selective μ opioid receptor agonist (IC50= 5.5 and > 10000 nM for inhibition of 125I-FK 33,824 and 125I-DADLE binding to μ and δ sites respectively). Although the affinity of PL017 for μ-sites is lower than that of morphine, PL 017 is more potent than morphine in all in vitro studies, suggesting a difference in the way in which peptide and alkaloid activate μ-receptors.

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