(2R*,4S*)-4-(3-Phosphonopropyl)-2-piperidinecarboxylic acid
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PPPA is a competitive NMDA receptor antagonist that displays moderate selectivity for NR2A-containing receptors (Ki=0.13, 0.47, 1.10 and 3.86 μM for GluN2A, GluN2B, GluN2C and GluN2D subunits respectively). Some findings support the hypothesis that PPPA and reward synergize to enhance initiate dopamine (DA) excitation.
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