RG-12525

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0	Negotiable

Min.Order :0
Purity: ≥98%

Keywords

NID 525 2-((4-((2-(1H-Tetrazol-5-ylmethyl)phenyl)methoxy)phenoxy)methyl)quinoline

Quick Details

Appearance:White to Yellow Solid
Application:For research use only.
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Storage:Store at 2-8°C for short term (days to weeks) or -20°C for long term (months to years)
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Details:

RG-12525 is a specific, competitive and orally effective antagonist of the peptidoleukotrienes, LTC4, LTD4 and LTE4, inhibiting LTC4-, LTD4- and LTE4-inducd guinea pig parenchymal strips contractions, with IC50s of 2.6, 2.5 and 7 nM, respectively. It is also a potent CYP3A4 inhibitor (Ki = 0.5 μM) and a peroxisome proliferator-activated receptor gamma (PPAR-γ) agonist with an IC50 of about 60 nM.

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