RS 25344

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Purity: >98 %

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RS-25344 1-(3-nitrophenyl)-3-(pyridin-4-ylmethyl)pyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione

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Appearance:White solid
Application:For research use only.
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RS 25344 is a potent and selective inhibitor of four cloned isoforms of PDE4 (A, B, C and D) and phosphorylated PDE4D (IC50 = 0.28, > 100, 160 and 330 nM at PDE4, PDE1, PDE2 and PDE3 respectively). It has been shown to inhibit eosinophil chemotaxis and increase progressive motility of spermatozoa in vitro.

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