(R)-3-[4-Cyano-3-[2-hydroxy-3-(2-indan-2-yl-1,1-dimethylethylamino)propoxy]phenyl]propionic acid ethyl ester (R)-ethyl 3-(4-cyano-3-(3-((1-(2,3-dihydro-1H-inden-2-yl)-2-methylpropan-2-yl)amino)-2-hydroxypropoxy)phenyl)propanoate
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SB-423557, a precursor of SB-423562, is an orally active calcium-sensing receptor (CaR) antagonist (IC50 = 520 nM). SB-423557 is well tolerated in human and increases plasma concentrations of exogenous parathyroid hormone (PTH) and stimulates bone formation.
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