SGI-110

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0	Negotiable

Min.Order :0
Purity: ≥95%

Keywords

Guadecitabine SGI 110

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Application:Antineoplastic Agents
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Storage:Store at -20°C
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SGI-110 is a dinucleotide antimetabolite of a decitabine linked via phosphodiester bond to a guanosine, with potential antineoplastic activity. Following metabolic activation by phosphorylation and incorporation into DNA, SGI-110 inhibits DNA methyltransferase, thereby causing genome-wide and non-specific hypomethylation and inducing cell cycle arrest at S-phase. This agent is resistant to cytidine deaminase, hence may result in gradual release of decitabine both extra- and intracellularly, leading to more prolonged exposures to decitabine.

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