T 98475 hydrochloride

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Purity: ≥95%

Keywords

Thieno[2,3-b]pyridine-5-carboxylic acid, 7-[(2,6-difluorophenyl)methyl]-4,7-dihydro-2-[4-[(2-methyl-1-oxopropyl)amino]phenyl]-3-[[methyl(phenylmethyl)amino]methyl]-4-oxo-, 1-methylethyl ester, hyd... Thieno[2,3-b]pyridine-5-carboxylic acid, 7-[(2,6-difluorophenyl)methyl]-4,7-dihydro-2-[4-[(2-methyl-1-oxopropyl)amino]phenyl]-3-[[methyl(phenylmethyl)amino]methyl]-4-oxo-, 1-methylethyl ester, mon...

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T 98475 is a potent, orally active and non-peptide gonadotropin-releasing hormone (GnRH, LHRH) receptor antagonist (IC50 = 0.2, 4.0 and 60 nM for human, monkey and rat GnRH receptors, respectively). T 98475 inhibits LH release in vitro (IC50 = 100 nM) and reduces plasma LH concentration in castrated male cynomolgus monkeys.

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