TEI-9647

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Min.Order :0
Purity: ≥95%

Keywords

(23S)-1alpha-hydroxy-25,27-didehydrovitamin D3 26,23-lactone (5Z,7E)-(1S,3R,23S)-1,3-dihydroxy-9,10-seco-5,7,10(19),25(27)-cholestatetraeno-26,23-lactone

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Appearance:White to Off-white Solid
Application:For research use only.
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Storage:Store at 2-8°C, protect from light, stored under nitrogen
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TEI-9647, a Vitamin D3 Lactone analogue, is a potent and specific vitamin D receptor (VDR) antagonist with the potential to inhibit excessive bone resorption and osteoclast formation in Paget's disease. It inhibits genomic effects of 1α,25(OH)2D3 mediated by VDR/VDRE, and inhibits 1α,25(OH)2D3-induced bone resorption and HL-60 cell differentiation.

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