TPA-023B

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Purity: ≥95%

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[1,1'-Biphenyl]-2-carbonitrile, 2',6-difluoro-5'-[3-(1-hydroxy-1-methylethyl)imidazo[1,2-b][1,2,4]triazin-7-yl]- 2',6-Difluoro-5'-(3-(2-hydroxypropan-2-yl)imidazo[1,2-b][1,2,4]triazin-7-yl)-[1,1'-biphenyl]-2-carbonitrile

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TPA-023B is an orally active and high-affinity GABAA receptor α2/α3 subtype partial agonist and α1 subtype antagonist with Kis of 0.73, 2 and 1.8 nM, respectively. It has non-sedating anxiolytic-like properties.

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