1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(trans-4-((5-(trifluoromethyl)pyridin-2-yl)oxy)cyclohexyl)urea
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UC2288 is a novel and orally active p21 attenuator (relatively selective activity for p21), which is synthesized based Sorafenib. UC2288 decreases p21 mRNA expression independently of p53, and attenuates p21 protein levels with minimal effect on p21 protein stability.
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