N,N'-1,8-WIN 18446 WIN18446
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WIN 18446 is an aldehyde dehydrogenase 1a2 (ALDH1a2) inhibitor (IC50 = 0.3 μM). WIN 18446 inhibits the biosynthesis of retinoic acid from retinol in neonatal and adult murine testis, and suppresses several gene expression regulated by retinoic acid.
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